Regulation of Cell Cycle

Mia Gonzalez
8 min read
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Study Guide Overview
This study guide covers the cell cycle, focusing on checkpoints (G1, G2, Metaphase), the Cdk-Cyclin complex, key genes like p53, cancerous cells, and apoptosis. It explains their roles in regulating cell division and how disruptions can lead to cancer. Practice questions and exam tips are also included.
#AP Biology: Cell Cycle Control - Your Last-Minute Guide π
Hey! Let's make sure you're totally prepped for the AP Bio exam. We'll break down cell cycle checkpoints, cancer, and apoptosis in a way that's super clear and easy to remember. Letβs get started!
#Cell Cycle Checkpoints: The Gatekeepers of Cell Division
Cell cycle checkpoints are like quality control stops during cell division. They make sure everything's perfect before the cell moves on. Think of them as the cell's safety net, preventing errors that could lead to big problems like cancer. π¦
- Why Checkpoints? To prevent mutations and ensure accurate cell division.
- Where are they?
- End of G1 phase
- G2 to M transition
- During Metaphase
These checkpoints are crucial to prevent uncontrolled cell growth and the formation of tumors. Remember, a cell that ignores these checkpoints can become cancerous. π‘
#G1 Checkpoint: The Growth Check
- Also known as the cell growth checkpoint.
- What it checks:
- Is the cell big enough?
- Does it have enough nutrients and proteins?
- Outcome:
- If everything's good, it moves to the S phase.
- If not, it enters the G0 phase (resting phase) until ready.
Think of G1 as the cell's "getting ready" phase. It's like making sure you have all your supplies before starting a big project. π
#G2 Checkpoint: The DNA Check
- Also known as the DNA synthesis checkpoint.
- What it checks:
- Has the DNA been replicated correctly during the S phase?
- Outcome:
- If DNA replication is perfect, it moves to the M (mitosis) phase.
- If not, it pauses for repairs.
DNA replication errors are a major cause of mutations. This checkpoint is like a spell-checker for your DNA. π
#Metaphase Checkpoint: The Alignment Check
- Occurs during the M (mitosis) phase.
- What it checks:
- Are all chromosomes correctly attached to the spindle fibers at metaphase?
- Outcome:
- If metaphase is complete, the cell divides.
- If not, it waits for proper alignment.
Remember the order: G1 (growth), S (DNA synthesis), G2 (prep for mitosis), M (mitosis). Use 'Go, Sally, Go, Make' as a mnemonic to help you. πββοΈ
#Visualizing the Checkpoints

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