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Glossary

C

Cell Communication

Criticality: 3

The intricate process by which cells send, receive, and respond to signals from each other and their external environment.

Example:

During embryonic development, cells engage in extensive cell communication to coordinate the formation of tissues and organs.

Cell Death (Apoptosis)

Criticality: 2

Programmed cell death, a controlled and orderly process that eliminates unwanted or damaged cells without causing inflammation.

Example:

During the development of human hands, the webbing between fingers is removed through apoptosis to create distinct digits.

Cell Differentiation

Criticality: 2

The process by which a less specialized cell becomes a more specialized cell type, acquiring distinct structures and functions.

Example:

An embryonic stem cell transforming into a neuron or a muscle cell is a prime example of cell differentiation.

Cellular Responses

Criticality: 3

The changes in cell function, behavior, or gene expression that occur as a direct result of a cell receiving and processing a signal.

Example:

Upon detecting a viral infection, an immune cell's cellular responses might include initiating programmed cell death or releasing antiviral proteins.

E

Environmental Factors

Criticality: 2

External conditions or stimuli, such as temperature, light, or chemical presence, that can influence cellular behavior and trigger responses.

Example:

A plant's leaves orienting towards sunlight is a direct response to environmental factors influencing its cellular processes.

G

Gene Expression

Criticality: 3

The process by which information encoded in DNA is used to synthesize a functional product, typically a protein, influencing a cell's characteristics.

Example:

When a cell needs to produce more digestive enzymes, it increases the gene expression of the specific genes coding for those enzymes.

Glucagon

Criticality: 3

A hormone produced by the pancreas that raises blood glucose levels by stimulating the liver to break down stored glycogen and release glucose into the bloodstream.

Example:

If you skip a meal, your pancreas releases glucagon to ensure your brain and other organs have a steady supply of glucose.

I

Insulin

Criticality: 3

A hormone produced by the pancreas that lowers blood glucose levels by promoting the uptake of glucose into body cells and its storage as glycogen in the liver.

Example:

After eating a carbohydrate-rich meal, your pancreas releases insulin to help your body manage the rise in blood sugar.

L

Ligand

Criticality: 3

A signaling molecule that binds specifically to a receptor, initiating a cellular response.

Example:

Neurotransmitters like serotonin act as ligands when they bind to specific receptors on nerve cells, transmitting signals in the brain.

M

Metabolism

Criticality: 2

The sum of all chemical processes that occur within a living organism to maintain life, including both the breakdown of substances for energy and the synthesis of new molecules.

Example:

When you exercise, your muscle cells increase their metabolism to rapidly produce ATP for muscle contraction.

Q

Quorum Sensing

Criticality: 2

A type of cell communication in bacteria where they coordinate gene expression and behavior based on population density, using secreted signaling molecules.

Example:

Bacteria forming a protective biofilm often rely on quorum sensing to collectively initiate the production of the extracellular matrix.

R

Receptor

Criticality: 3

A protein, typically located on the cell surface or within the cytoplasm, that specifically binds to a signaling molecule (ligand) and initiates a cellular response.

Example:

The taste buds on your tongue contain specific receptors that bind to different molecules, allowing you to perceive sweet, sour, salty, bitter, and umami flavors.

S

Signal Transduction

Criticality: 3

The multi-step process where an extracellular signal is converted into a specific intracellular response, often involving a cascade of molecular events.

Example:

When adrenaline binds to a heart cell, a rapid signal transduction pathway leads to an increased heart rate.